Meister Group

PI:
Gunter Meister, full professor, PhD
Participating group members:
Ph.D. studs Daniele Hasler and Nicholas Putz, Post docs Thomas Treiber, Nora Treiber and Susanne Roether.
Address:
Department of Biochemistry, Regensburg Center for Biochemistry and Biophysics, University of Regensburg. email: Gunter.Meister@vkl.uni-regensburg.de

Profile of the group:

G. Meister heads the Biochemistry I department of the University of Regensburg and is a member of the Bavarian Genome Research Network (BayGene). GM was an independent group leader at the Max-Planck-Institute of Biochemistry (Martinsried,Germany) from 2005-2010. Since 2009, GM is full professor at the University of Regensburg. During the last years, GM has obtained steady and considerable external funding (e.g. ERC starting grant). He is supervising 7 postdocs and has educated 6 PhD students. GMs group has a strong track record in the biochemical characterization of RNA protein complexes. Currently, the group works on the characterization of human Argonaute (Ago) protein-containing complexes, which hold small ncRNAs and therefore are promising tools to identify novel classes of small regulatory ncRNAs. The group has pioneered the characterization of enzymatic activities within small RNA-guided gene silencing pathways and has published important and highly cited papers on these activities. More recently, the research has shifted towards a better understanding of nuclear small RNA functions as well as the interplay between small RNAs and long ncRNAs in human cells. Finally, the group of GM has started to characterize RNA protein complexes on the atomic level using X-ray crystallography. The strong international standing of GM in small RNA-guided gene silencing is indicated by high profile publications, many invited talks, assignments as reviewer for publications and grants as well as international collaborations (ONCOMIRS, SIROCCO, EUROCORES).

Publications:

  • Weinmann, L., Höck, J., Ivacevic T., Ohrt T., Mütze J., Schwille P., Kremmer E., Benes V., Urlaub, H., & Meister G. (2009) Importin 8 is a gene silencing factor that targets Argonaute proteins to distinct mRNAs. Cell, 136, 496-507.
  • Ender C., Krek A., Friedländer M.R., Beitzinger M., Weinmann L., Chen W., Pfeffer S., Rajewsky N. & Meister G. (2008) A human snoRNA with microRNA-like functions. Molecular Cell, 32, 519-528.
  • Meister G., Landthaler M., Patkaniowska A., Dorsett Y., Teng G. & Thomas Tuschl (2004) Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Molecular Cell, 15, 185-197.