Jensen Group

PI:
Torben Heick Jensen, full professor, PhD
Participating group members:
Evgenia Ntini, Pia Andersen, Maiken Kristiansen, Peter R. Andersen
Address etc.:
Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, Aarhus University, Denmark. email: thj@mb.au.dk

Profile of the group:

THJ is heading the Danish National Research Foundation funded centre of Excellence: Centre for mRNP Biogenesis and Metabolism. Moreover he is the chairman of the research committee at Department of Molecular Biology, Aarhus University with the responsibility of recruiting new personnel at the group leader level. THJ is full professor at Aarhus University since 2010. The THJ group holds a current size of 1 professor, 2 associate professors, 1 assistant professor, 2 senior researchers, 6 postdocs, 8 Ph.D. students, 2 M.Sc. student and 4 technicians. 7 M.Sc. students and 2 Ph.Ds have graduated. The THJ group has a strong international standing in the field of quality control of RNAs from both yeast and human cells. The group has co-pioneered work on the hidden transcriptome of human cells, including the discovery of new RNAs that are normally degraded by RNA turnover machineries of the cell as well as small RNAs (12-100nt in length) that are expressed from near or within human genic regions. Other recent work includes the discovery and characterization of new components of the human RNA exosome and the functional cross-talk between RNA processing. THJ has been an EMBO Young Investigator and has received the prestigious Hallas Møller stipend from the Novo Nordisk Foundation.

Publications:

  • Valen E., Preker P., Andersen P.R., Zhaou X., Chen Y., Ender C., Meister G., Sandelin A., Jensen T.H.: Small RNA profiles from human genic regions suggest biogenic mechanisms and identify new putative regulatory molecules. Nat Struct Mol Biol. (2011) Under revision after positive reviews. )
  • Mapendano C.K., Lykke-Andersen S., Kjems J., Bertrand E. and Jensen T.H.: Crosstalk between mRNA 3 end processing and transcription initiation. Molecular Cell (2010) 410-422.)
  • Tomecki R., Kristiansen M.S., Lykke-Andersen S., Chlebowski A., Larsen K.M., Szczesny R.J., Drazkowska K., Pastula A., Andersen J.S., Stepien P.P., Dziembowski A. and Jensen T.H.: The human core exosome binds to differentially localized processive ribonucleases: hDIS3 and hDIS3L. EMBO J. (2010) 2342 – 2357)
  • Jimeno-Gonzalez S., Haaning L.L., Malagon F. and Jensen T.H. : The yeast 5-3 exonuclease Rat1p functions during transcription elongation by RNA polymerase II. Molecular Cell (2010) 580-587)
  • Eberle A., Lykke-Andersen S., Muhlemann O. and Jensen T.H.: SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells. Nat Struct Mol Biol. (2009) 49-55. )
  • Preker P., Nielsen J., Kammler S., Lykke-Andersen S., Christensen M.S., Mapendano C.K., Schierup M. and Jensen T.H.: RNA exosome depletion reveals transcription upstream of active human promoters. Science (2008) 1851-1854. )
  • Saguez C., Schmid M., Olesen J.R., Ghazy M., Poulsen M.B., Nasser T., Moore C. and Jensen T.H.: Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Molecular Cell (2008) 91-103.)
  • Rougemaille M., Olesen J.R., Thomsen R., Seraphin B., Libri D. and Jensen T.H.: Dissecting mechanisms of mRNA surveillance in THO/sub2 complex mutants. EMBO J. (2007) 2317-2326)
  • Jensen T.H., Boulay J., Olsen J.R., Colin J., Weyler M. and Libri D.: Modulation of transcription affects mRNP quality. Molecular Cell (2004) 235-244.)
  • Hilleren P., McCarthy T., Rosbash M., Parker R. and Jensen T.H.: Quality control of mRNA 3-end processing is linked to the nuclear exosome. Nature (2001) 538-542.)